| S10E01 | | September 19, 2022 NBC | 45 | |
| S10E02 | Kaley Cuoco, Mike Birbiglia, Ari Lennox | September 20, 2022 NBC | 45 | |
| S10E03 | Eli Manning, Chef José Andrés, Ana Fabrega, Michael Rowland | September 21, 2022 NBC | 45 | |
| S10E04 | Tyler Perry, Stephen A. Smith, Blood Orange | September 22, 2022 NBC | 45 | |
| S10E05 | Jon Hamm, Jurnee Smollett, The Smashing Pumpkins | September 23, 2022 NBC | 45 | |
| S10E06 | Nick Kroll, Jenna Bush Hager, Raymond Lee, Colum Tyrrell | September 26, 2022 NBC | 45 | |
| S10E07 | Kelly Ripa, Kid Cudi, Kid Cudi ft. Ty Dolla $ign | September 27, 2022 NBC | 45 | |
| S10E08 | Miles Teller, Idina Menzel, Babyface ft. Baby Tate | September 28, 2022 NBC | 45 | |
| S10E09 | Robert De Niro, Chloe Fineman, Arctic Monkeys | September 29, 2022 NBC | 45 | |
| S10E10 | Zac Efron, Debbie Harry, Lea Michele | September 30, 2022 NBC | 45 | |
| S10E11 | Naomi Watts, Jacob Batalon, Justin Thomas, Sam Hunt | October 3, 2022 NBC | 45 | |
| S10E12 | Ralph Macchio, Jennifer Beals, Lea Thompson, Modern English | October 4, 2022 NBC | 45 | |
| S10E13 | Reese Witherspoon, Kevin Nealon, Sabrina Wu | October 5, 2022 NBC | 45 | |
| S10E14 | | October 6, 2022 NBC | 45 | |
| S10E15 | Mike Myers, Sutton Foster, Killer Mike | October 7, 2022 NBC | 45 | |
| S10E16 | Rachel Maddow, Noah Centineo, Fabien Frankel, Remi Wolf | October 10, 2022 NBC | 45 | |
| S10E17 | Pierce Brosnan, Charlie Puth, Kate del Castillo | October 11, 2022 NBC | 45 | |
| S10E18 | Dwayne Johnson, Camila Cabello, Ian Lara | October 12, 2022 NBC | 45 | |
| S10E19 | Trevor Noah, Antoni Porowski, Andrea Campos, Lil Baby | October 13, 2022 NBC | 45 | |
| S10E20 | Taylor Swift, Meghan Trainor | October 24, 2022 NBC | 45 | |
| S10E21 | | October 25, 2022 NBC | 45 | |
| S10E22 | Jim Parsons, Rose Byrne, Isabel Hagen | October 26, 2022 NBC | 45 | |
| S10E23 | Millie Bobby Brown, Michael Imperioli, Tegan and Sara | October 27, 2022 NBC | 45 | |
| S10E24 | Lin-Manuel Miranda, Bobby Cannavale, JVKE | October 28, 2022 NBC | 45 | |
| S10E25 | Daniel Radcliffe, Winston Duke, Caroline Rhea | October 31, 2022 NBC | 45 | |
| S10E26 | Lupita Nyong'o, “Weird Al” Yankovic, Cameron Crowe, cast of Almost Famous | November 1, 2022 NBC | 45 | |
| S10E27 | George Lopez, Cole Hauser, LaTanya Richardson Jackson, Joey Bada$$ with Men I Trust | November 2, 2022 NBC | 45 | |
| S10E28 | Hasan Minhaj, Bashir Salahuddin, Diallo Riddle, Paramore | November 3, 2022 NBC | 45 | |
| S10E29 | Mariah Carey, Marcus Mumford, Marcus Mumford ft. Monica Martin | November 4, 2022 NBC | 45 | |
| S10E30 | Ryan Reynolds, Jen Psaki, Smino | November 7, 2022 NBC | 45 | |
| S10E31 | Octavia Spencer, Matthias Schweighöfer, Kurt Braunohler | November 9, 2022 NBC | 45 | |
| S10E32 | Will Ferrell, Lindsay Lohan, The 1975 | November 10, 2022 NBC | 45 | |
| S10E33 | Sylvester Stallone, Linda Cardellini, Louis Tomlinson | November 11, 2022 NBC | 45 | |
| S10E34 | Bruce Springsteen, Chloë Grace Moretz | November 14, 2022 NBC | 45 | |
| S10E35 | Seth Rogen, Jeremy Pope, Bruce Springsteen | November 15, 2022 NBC | 45 | |
| S10E36 | Anya Taylor-Joy, Glen Powell, Patti Smith, Bruce Springsteen | November 16, 2022 NBC | 45 | |
| S10E37 | Jessica Chastain, Martha Stewart, The Smile | November 17, 2022 NBC | 45 | |
| S10E38 | Samuel L. Jackson, Neal Brennan, Wizkid | November 18, 2022 NBC | 45 | |
| S10E39 | Tim Allen, Lacey Chabert, From “Bluey” Dave McCormack and Melanie Zanetti, Brent Faiyaz | November 21, 2022 NBC | 45 | |
| S10E40 | Michael Strahan, Chef Daniel Humm, Cole Swindell | November 22, 2022 NBC | 45 | |
| S10E41 | Jesse Eisenberg, Madelyn Cline, Jacques Pépin | November 23, 2022 NBC | 45 | |
| S10E42 | Jerry Seinfeld, Adam Devine, Bruce Springsteen | November 24, 2022 NBC | 45 | |
| S10E43 | | November 28, 2022 NBC | 45 | |
| S10E44 | Whoopi Goldberg, Sam Worthington, Gabriel LaBelle, Manuel Turizo | November 29, 2022 NBC | 45 | |
| S10E45 | | November 30, 2022 NBC | 45 | |
| S10E46 | Adam Sandler, Greta Gerwig, Dane Cook, Babyface Ray | December 1, 2022 NBC | 45 | |
| S10E47 | Kevin Bacon, Theo James, Jay Jurden | December 2, 2022 NBC | 45 | |
| S10E48 | Selena Gomez, Sebastian Maniscalco, beabadoobee | December 5, 2022 NBC | 45 | |
| S10E49 | Emma Thompson, Guillermo del Toro, Ashley McBryde and John Osborne | December 6, 2022 NBC | 45 | |
| S10E50 | Michelle Pfeiffer, Lil Rel Howery, Clive Davis, Goose | December 7, 2022 NBC | 45 | |
| S10E51 | | December 8, 2022 NBC | 45 | |
| S10E52 | Miley Cyrus, Jesse Williams, Mary Mack | December 9, 2022 NBC | 45 | |
| S10E53 | Kate Hudson, Morris Chestnut, cast of A Beautiful Noise | December 12, 2022 NBC | 45 | |
| S10E54 | | December 13, 2022 NBC | 45 | |
| S10E55 | Salma Hayek Pinault, Wiz Khalifa | December 14, 2022 NBC | 45 | |
| S10E56 | | December 15, 2022 NBC | 45 | |
| S10E57 | James Corden, Jenna Ortega, Mike Feeney | December 16, 2022 NBC | 45 | |
| S10E58 | Ana de Armas, Luke Grimes, Protoje | January 3, 2023 NBC | 45 | |
| S10E59 | Winston Duke, Darren Aronofsky, Emma Myers, IDLES | January 4, 2023 NBC | 45 | |
| S10E60 | | January 5, 2023 NBC | 45 | |
| S10E61 | Allison Williams, Jerrod Carmichael, Jessie Reyez | January 6, 2023 NBC | 45 | |
| S10E62 | | January 9, 2023 NBC | 45 | |
| S10E63 | Leslie Jones, Giancarlo Esposito, Alvvays | January 10, 2023 NBC | 45 | |
| S10E64 | | January 11, 2023 NBC | 45 | |
| S10E65 | Chelsea Handler, Matthew Macfadyen, Ralph Barbosa | January 12, 2023 NBC | 45 | |
| S10E66 | Lea Michele, Sadie Sink, Dayglow | January 13, 2023 NBC | 45 | |
| S10E67 | Aubrey Plaza, Jalyn Hall, Sudan Archives | January 16, 2023 NBC | 45 | |
| S10E68 | Katie Holmes, Danielle Deadwyler, Anuel AA | January 17, 2023 NBC | 45 | |
| S10E69 | Yara Shahidi, John Leguizamo, SG Lewis | January 18, 2023 NBC | 45 | |
| S10E70 | John Oliver, Sam Smith, Fahim Anwar | January 19, 2023 NBC | 45 | |
| S10E71 | Colin Jost, Kenya Barris, Tobe Nwigwe | January 20, 2023 NBC | 45 | |
| S10E72 | Aaron Judge, Josh Duhamel, Freddie Gibbs ft. Anderson .Paak | January 23, 2023 NBC | 45 | |
| S10E73 | | January 24, 2023 NBC | 45 | |
| S10E74 | Keke Palmer, Jeff Gordon, Lauren London, HARDY ft. Lainey Wilson | January 25, 2023 NBC | 45 | |
| S10E75 | Michael B. Jordan, Hugh Dancy, Måneskin, Tom Morello | January 26, 2023 NBC | 45 | |
| S10E76 | Claire Danes, Roman Reigns, Cathy Ladman | January 27, 2023 NBC | 45 | |
| S10E77 | Austin Butler, Rob Gronkowski, Tyler Hubbard | January 30, 2023 NBC | 45 | |
| S10E78 | Dave Bautista, Sarah Michelle Gellar, Bryan Adams | January 31, 2023 NBC | 45 | |
| S10E79 | Derek Jeter, Rita Ora | February 1, 2023 NBC | 45 | |
| S10E80 | Pedro Pascal, Kathryn Newton, Armani White | February 2, 2023 NBC | 45 | |
| S10E81 | | February 3, 2023 NBC | 45 | |
| S10E82 | Ashton Kutcher, Alison Brie, Dermot Kennedy | February 6, 2023 NBC | 45 | |
| S10E83 | | February 7, 2023 NBC | 45 | |
| S10E84 | Queen Latifah, M. Night Shyamalan, Orlando Leyba | February 8, 2023 NBC | 45 | |
| S10E85 | Matthew McConaughey, Evangeline Lilly, Jorma Taccone, Lang Lang | February 9, 2023 NBC | 45 | |
| S10E86 | Paul Rudd, Marc Maron, Kelela | February 10, 2023 NBC | 45 | |
| S10E87 | Elizabeth Banks, Kelsey Grammer, Chef Jordan Andino | February 13, 2023 NBC | 45 | |
| S10E88 | | February 14, 2023 NBC | 45 | |
| S10E89 | Liam Neeson, Jack Whitehall, Nate Smith | February 15, 2023 NBC | 45 | |
| S10E90 | Travis Kelce, Jay Hernandez, Samara Joy | February 16, 2023 NBC | 45 | |
| S10E91 | Adam Scott, Elizabeth Debicki, Nathan Macintosh | February 17, 2023 NBC | 45 | |
| S10E92 | Gigi Hadid, Chase Stokes, Micky Dolenz, Dierks Bentley | February 27, 2023 NBC | 45 | |
| S10E93 | Willem Dafoe, Marlon Wayans, Macklemore, Kelsey Cook | February 28, 2023 NBC | 45 | |
| S10E94 | Ice T, Stephanie Hsu, Adam Lambert | March 1, 2023 NBC | 45 | |
| S10E95 | Brendan Fraser, Tan France, Lizzy McAlpine | March 2, 2023 NBC | 45 | |
| S10E96 | Tessa Thompson, Andy Cohen, The National | March 3, 2023 NBC | 45 | |
| S10E97 | Chance the Rapper, Maude Apatow | March 6, 2023 NBC | 45 | |
| S10E98 | Adam Driver, Ana Gasteyer, Macklemore ft. Morray | March 7, 2023 NBC | 45 | |
| S10E99 | | March 8, 2023 NBC | 45 | |
| S10E100 | Jenna Ortega, Hannah Waddingham, TWICE | March 9, 2023 NBC | 45 | |
| S10E101 | | March 10, 2023 NBC | 45 | |
| S10E102 | Bob Odenkirk, Paris Hilton, Collin Morikawa, Asake | March 13, 2023 NBC | 45 | |
| S10E103 | Bryan Cranston, Penn Badgley, Maya Hawke | March 14, 2023 NBC | 45 | |
| S10E104 | Keira Knightley, Zachary Levi, Rina Sawayama, Nore Davis | March 15, 2023 NBC | 45 | |
| S10E105 | | March 16, 2023 NBC | 45 | |
| S10E106 | | March 17, 2023 NBC | 45 | |
| S10E107 | | March 20, 2023 NBC | 45 | |
| S10E108 | Jennifer Aniston, Sarah Snook, Preacher Lawson | March 21, 2023 NBC | 45 | |
| S10E109 | Brian Cox, Heidi Gardner, Mikaela Shiffrin, Caroline Polachek | March 22, 2023 NBC | 45 | |
| S10E110 | Kiefer Sutherland, Jimin, Fall Out Boy | March 23, 2023 NBC | 45 | |
| S10E111 | Kieran Culkin, Method Man, Jimin | March 24, 2023 NBC | 45 | |
| S10E112 | Nathan Lane, Dove Cameron, Lil Uzi Vert | March 27, 2023 NBC | 45 | |
| S10E113 | | March 28, 2023 NBC | 45 | |
| S10E114 | Kevin Bacon, Jay Pharoah, Coco Jones | March 29, 2023 NBC | 45 | |
| S10E115 | Edward Norton, Ego Nwodim, Parker McCollum | March 30, 2023 NBC | 45 | |
| S10E116 | Chris Pratt, Elizabeth Vargas, Maisie Peters | March 31, 2023 NBC | 45 | |
| S10E117 | Michelle Williams, John Stamos, Mo Willems, CHVRCHES | April 3, 2023 NBC | 45 | |
| S10E118 | Keegan-Michael Key, Sir Richard Branson, Blondshell | April 4, 2023 NBC | 45 | |
| S10E119 | Matt Damon, Cecily Strong, Rema | April 5, 2023 NBC | 45 | |
| S10E120 | Molly Shannon, Ramón Rodríguez, Sophie Buddle | April 6, 2023 NBC | 45 | |
| S10E121 | Jonas Brothers, Chlöe Bailey, The Foodie Magician | April 7, 2023 NBC | 45 | |
| S10E122 | Chris Evans, Lord Andrew Lloyd Webber, Toosii | April 17, 2023 NBC | 45 | |
| S10E123 | Ana de Armas, Jesse Plemons, Mike Vecchione | April 18, 2023 NBC | 45 | |
| S10E124 | Michelle Obama, Kelvin Harrison Jr., Sampa the Great ft. Angélique Kidjo | April 19, 2023 NBC | 45 | |
| S10E125 | Ray Romano, Zoe Lister-Jones, FLO | April 20, 2023 NBC | 45 | |
| S10E126 | Sienna Miller, Nikolaj Coster-Waldau, Gabriel Basso, Ryan Hamilton | April 21, 2023 NBC | 45 | |
| S10E127 | Kate Beckinsale, Rainn Wilson, Romeo Santos | April 24, 2023 NBC | 45 | |
| S10E128 | Jude Law, Joshua Jackson, Jackie Fabulous | April 25, 2023 NBC | 45 | |
| S10E129 | | April 26, 2023 NBC | 45 | |
| S10E130 | Drew Barrymore, Lizzy Caplan, Young Mazino, The National | April 27, 2023 NBC | 45 | |
| S10E131 | | April 28, 2023 NBC | 45 | |
| S10E132 | Rosie O'Donnell, SUGA season finale | May 1, 2023 NBC | 45 | |
