| S08E01 | Julianne Moore, Chace Crawford, Polo G | September 21, 2020 NBC | 45 | |
| S08E02 | Keira Knightley, Chelsea Clinton, Tame Impala | September 22, 2020 NBC | 45 | |
| S08E03 | | September 23, 2020 NBC | 45 | |
| S08E04 | Chris Rock, Jonathan Majors, Sasha Sloan | September 24, 2020 NBC | 45 | |
| S08E05 | Sting, Gugu Mbatha-Raw, Gashi ft. Sting | September 25, 2020 NBC | 45 | |
| S08E06 | Jim Parsons, Shepard Smith, BTS | September 28, 2020 NBC | 45 | |
| S08E07 | John Cena, BTS | September 29, 2020 NBC | 45 | |
| S08E08 | BTS, Chris Colfer, Tampa Bay Lightning | September 30, 2020 NBC | 45 | |
| S08E09 | | October 1, 2020 NBC | 45 | |
| S08E10 | Adam Sandler, Millie Bobby Brown, BTS | October 2, 2020 NBC | 45 | |
| S08E11 | | October 5, 2020 NBC | 45 | |
| S08E12 | | October 6, 2020 NBC | 45 | |
| S08E13 | Maya Rudolph, Matt Bomer, 070 Shake | October 7, 2020 NBC | 45 | |
| S08E14 | Eddie Redmayne, Guy Raz, Lele Pons X Guaynaa | October 8, 2020 NBC | 45 | |
| S08E15 | Kevin James, Lenny Kravitz, Nate Bargatze | October 9, 2020 NBC | 45 | |
| S08E16 | | October 19, 2020 NBC | 45 | |
| S08E17 | Natalie Portman, Billy Porter, Lous and the Yakuza | October 20, 2020 NBC | 45 | |
| S08E18 | Anthony Mackie, Lily James, Black Thought ft. Portugal. the Man and the Last Artful, Dodgr | October 21, 2020 NBC | 45 | |
| S08E19 | Julia Louis-Dreyfus, Patton Oswalt, Of Monsters and Men | October 22, 2020 NBC | 45 | |
| S08E20 | Chelsea Handler, Senator Bernie Sanders, The War on Drugs | October 23, 2020 NBC | 45 | |
| S08E21 | Sterling K. Brown, Zoe Lister-Jones, Matthew 'Super' Delisi, Rina Sawayama | October 26, 2020 NBC | 45 | |
| S08E22 | Shawn Mendes, Tig Notaro | October 27, 2020 NBC | 45 | |
| S08E23 | Ken Jeong, Mayor Pete Buttigieg, Sam Hunt | October 28, 2020 NBC | 45 | |
| S08E24 | America Ferrera, David Dobrik, Corey Seager, Brothers Osborne | October 29, 2020 NBC | 45 | |
| S08E25 | Nick Offerman, Stacey Abrams, Busta Rhymes ft. Anderson .Paak | October 30, 2020 NBC | 45 | |
| S08E26 | | November 2, 2020 NBC | 45 | |
| S08E27 | | November 4, 2020 NBC | 45 | |
| S08E28 | Kenan Thompson, Kate Mara, James Blake | November 5, 2020 NBC | 45 | |
| S08E29 | Milo Ventimiglia, Marc Maron, Oneohtrix Point Never | November 6, 2020 NBC | 45 | |
| S08E30 | Kaley Cuoco, Megan Rapinoe, Josh Johnson | November 9, 2020 NBC | 45 | |
| S08E31 | Vince Vaughn, Lorraine Bracco, Gus Dapperton | November 10, 2020 NBC | 45 | |
| S08E32 | Michael Strahan, Brené Brown, Patty Smyth | November 11, 2020 NBC | 45 | |
| S08E33 | | November 12, 2020 NBC | 45 | |
| S08E34 | Post Malone, Phoebe Robinson, 2 Chainz | November 13, 2020 NBC | 45 | |
| S08E35 | Chance the Rapper, Erin Andrews, G Herbo x Chance the Rapper | November 16, 2020 NBC | 45 | |
| S08E36 | Whoopi Goldberg, Emma Corrin, Dierks Bentley | November 17, 2020 NBC | 45 | |
| S08E37 | Dan Levy, Michael J. Fox, Julia Michaels | November 18, 2020 NBC | 45 | |
| S08E38 | Sarah Paulson, Henry Golding, Car Seat Headrest | November 19, 2020 NBC | 45 | |
| S08E39 | Leslie Mann, Colin Quinn, SAINt JHN | November 20, 2020 NBC | 45 | |
| S08E40 | Emma Stone, Ben Falcone, Josh Groban | November 23, 2020 NBC | 45 | |
| S08E41 | | November 24, 2020 NBC | 45 | |
| S08E42 | Melissa McCarthy, The Original Cast of “Saved By The Bell,” Sheryl Crow | November 25, 2020 NBC | 45 | |
| S08E43 | Jerry Seinfeld, Bad Bunny | November 26, 2020 NBC | 45 | |
| S08E44 | Nick Kroll, Lily Collins, Matt Berninger | November 30, 2020 NBC | 45 | |
| S08E45 | | December 1, 2020 NBC | 45 | |
| S08E46 | Jamie Dornan, Lisa Robinson, Phoebe Bridgers | December 2, 2020 NBC | 45 | |
| S08E47 | Jason Bateman, Carrie Underwood | December 3, 2020 NBC | 45 | |
| S08E48 | Barack Obama, Liam Gallagher | December 4, 2020 NBC | 45 | |
| S08E49 | Mariah Carey, Andrew Rannells, José Feliciano | December 7, 2020 NBC | 45 | |
| S08E50 | Taraji P. Henson, Chloe Fineman, FINNEAS | December 8, 2020 NBC | 45 | |
| S08E51 | | December 9, 2020 NBC | 45 | |
| S08E52 | Bruce Springsteen, J. Balvin, Mandy Moore | December 10, 2020 NBC | 45 | |
| S08E53 | | December 11, 2020 NBC | 45 | |
| S08E54 | Gal Gadot, Ricky Martin, Lana Del Rey | December 14, 2020 NBC | 45 | |
| S08E55 | Kristen Wiig, Graham Norton, Jack Harlow | December 15, 2020 NBC | 45 | |
| S08E56 | Tina Fey, Patty Jenkins, Marcus King | December 16, 2020 NBC | 45 | |
| S08E57 | Paul McCartney, Pedro Pascal, The Voidz | December 17, 2020 NBC | 45 | |
| S08E58 | Olivia Colman, Lucas Hedges, Barry Gibb, Jhené Aiko, Nas | December 18, 2020 NBC | 45 | |
| S08E59 | Gordon Ramsay, Vanessa Kirby, Sturgill Simpson | January 4, 2021 NBC | 45 | |
| S08E60 | Gwen Stefani, Ralph Macchio | January 5, 2021 NBC | 45 | |
| S08E61 | Dan Rather, Don Cheadle, Katy Tur, Michael Kiwanuka | January 6, 2021 NBC | 45 | |
| S08E62 | Ricky Gervais, Daisy Edgar-Jones, The Avett Brothers | January 7, 2021 NBC | 45 | |
| S08E63 | Rob Lowe, Lil Nas X, Regé-Jean Page, Mark Normand | January 8, 2021 NBC | 45 | |
| S08E64 | Rashida Jones, Bill Burr, Old Dominion | January 11, 2021 NBC | 45 | |
| S08E65 | Anne Hathaway, Lilly Singh, Jazmine Sullivan | January 12, 2021 NBC | 45 | |
| S08E66 | Riz Ahmed, Angela Bassett, Jacob Collier ft. Mahalia | January 13, 2021 NBC | 45 | |
| S08E67 | Anthony Mackie, Cristin Milioti, Rico Nasty | January 14, 2021 NBC | 45 | |
| S08E68 | Nicole Kidman, Cole Sprouse, Henry Hall | January 15, 2021 NBC | 45 | |
| S08E69 | | January 18, 2021 NBC | 45 | |
| S08E70 | Dakota Johnson, Yara Shahidi, Tate McRae | January 19, 2021 NBC | 45 | |
| S08E71 | | January 20, 2021 NBC | 45 | |
| S08E72 | Shaquille O'Neal, Alison Brie, Pa Salieu | January 21, 2021 NBC | 45 | |
| S08E73 | Rosario Dawson, Daveed Diggs, Amanda Shires ft. Jason Isbell | January 22, 2021 NBC | 45 | |
| S08E74 | Jared Leto, Jane Lynch, Jade Bird | January 25, 2021 NBC | 45 | |
| S08E75 | Susan Sarandon, J.J. Watt, Thad co*ckrell | January 26, 2021 NBC | 45 | |
| S08E76 | Rami Malek, Bridget Everett, Jesus Trejo | January 27, 2021 NBC | 45 | |
| S08E77 | Keegan-Michael Key, Terry Gross, Fontaines D.C. | January 28, 2021 NBC | 45 | |
| S08E78 | Justin Timberlake, London Hughes, Ozuna x Anuel AA | January 29, 2021 NBC | 45 | |
| S08E79 | Bryan Cranston, John Cena, Remi Wolf | February 1, 2021 NBC | 45 | |
| S08E80 | Drew Barrymore, Talib Kweli, Nilüfer Yanya | February 2, 2021 NBC | 45 | |
| S08E81 | Kelly Ripa, JoJo Siwa, M. Night Shyamalan | February 3, 2021 NBC | 45 | |
| S08E82 | | February 4, 2021 NBC | 45 | |
| S08E83 | Dolly Parton, Noah Centineo, Slowthai ft. Skepta | February 5, 2021 NBC | 45 | |
| S08E84 | Dave Grohl, Joel Kinnaman, Foo Fighters | February 8, 2021 NBC | 45 | |
| S08E85 | Priyanka Chopra Jonas, LaKeith Stanfield, Rob Gronkowski, Joy Oladokun | February 9, 2021 NBC | 45 | |
| S08E86 | Dwayne Johnson, Daniel Kaluuya, Chris Stapleton | February 10, 2021 NBC | 45 | |
| S08E87 | Cardi B, Alex Moffat, Lang Lang | February 11, 2021 NBC | 45 | |
| S08E88 | Kenan Thompson, Lana Condor, Fireboy DML | February 12, 2021 NBC | 45 | |
| S08E89 | Shailene Woodley, Henry Louis Gates Jr., Kenice Mobley | February 22, 2021 NBC | 45 | |
| S08E90 | Tom Holland, Andra Day | February 23, 2021 NBC | 45 | |
| S08E91 | Awkwafina, Ava DuVernay, Mary McCartney, Chloe X Halle | February 24, 2021 NBC | 45 | |
| S08E92 | Eddie Murphy, Eve Hewson, The Kid LAROI | February 25, 2021 NBC | 45 | |
| S08E93 | Queen Latifah, Paris Hilton, The Network | February 26, 2021 NBC | 45 | |
| S08E94 | John Legend, Jermaine Fowler, Arlo Parks | March 1, 2021 NBC | 45 | |
| S08E95 | Nick Jonas, Rita Ora | March 2, 2021 NBC | 45 | |
| S08E96 | | March 3, 2021 NBC | 45 | |
| S08E97 | Tracy Morgan, Sam Heughan, Pete Lee | March 4, 2021 NBC | 45 | |
| S08E98 | Amanda Seyfried, Omar Sy, Lil Durk ft. 6Lack | March 5, 2021 NBC | 45 | |
| S08E99 | Amy Poehler, Courtney B. Vance, Willie Jones | March 8, 2021 NBC | 45 | |
| S08E100 | Chrissy Teigen, Rory McIlroy, Pink Sweat$ ft. Kehlani | March 9, 2021 NBC | 45 | |
| S08E101 | | March 10, 2021 NBC | 45 | |
| S08E102 | Jennifer Garner, Don Lemon, Adrianne Lenker | March 11, 2021 NBC | 45 | |
| S08E103 | | March 12, 2021 NBC | 45 | |
| S08E104 | John Oliver, Brian Tyree Henry, Japanese Breakfast | March 15, 2021 NBC | 45 | |
| S08E105 | Benedict Cumberbatch, Madelaine Petsch, Rosé | March 16, 2021 NBC | 45 | |
| S08E106 | Jerry Seinfeld, Taylor Kinney, Camilo | March 17, 2021 NBC | 45 | |
| S08E107 | | March 18, 2021 NBC | 45 | |
| S08E108 | Matthew McConaughey, Megan Rapinoe, Morris Day ft. Trinidad Jame$ | March 19, 2021 NBC | 45 | |
| S08E109 | Tracee Ellis Ross, Andy Cohen, Aaron Frazer | March 22, 2021 NBC | 45 | |
| S08E110 | Chelsea Handler, Russell Brand, Mary Beth Barone | March 23, 2021 NBC | 45 | |
| S08E111 | Alexander Skarsgård, Karol G | March 24, 2021 NBC | 45 | |
| S08E112 | Maya Rudolph, Christopher Meloni, 24kGoldn | March 25, 2021 NBC | 45 | |
| S08E113 | Viola Davis, Addison Rae | March 26, 2021 NBC | 45 | |
| S08E114 | Milo Ventimiglia, The Lucas Brothers, Lil Tjay ft. 6LACK | April 5, 2021 NBC | 45 | |
| S08E115 | Pete Davidson, Gaten Matarazzo, Glass Animals | April 6, 2021 NBC | 45 | |
| S08E116 | Denis Leary, Cristin Milioti, Rod Wave | April 7, 2021 NBC | 45 | |
| S08E117 | Carey Mulligan, Caleb McLaughlin, Kali Uchis | April 8, 2021 NBC | 45 | |
| S08E118 | Demi Lovato, Alan Kim | April 9, 2021 NBC | 45 | |
| S08E119 | Snoop Dogg, H.E.R. | April 12, 2021 NBC | 45 | |
| S08E120 | Joseph Gordon-Levitt, Phoebe Robinson, Celeste | April 13, 2021 NBC | 45 | |
| S08E121 | Allison Janney, Ṣọpẹ́,Dìrísù, Pooh Shiesty | April 14, 2021 NBC | 45 | |
| S08E122 | Ice T, Mike Birbiglia, Orlando Leyba | April 15, 2021 NBC | 45 | |
| S08E123 | | April 16, 2021 NBC | 45 | |
| S08E124 | Michael Strahan, Tig Notaro, Emmy Blotnick | April 19, 2021 NBC | 45 | |
| S08E125 | Jane Fonda, Robin Thede, Joy Reid, Alanis Morissette | April 20, 2021 NBC | 45 | |
| S08E126 | Elisabeth Moss, James Cameron, Carlos Vives x Ricky Martin | April 21, 2021 NBC | 45 | |
| S08E127 | Kevin Bacon, Simone Biles, Ritt Momney | April 22, 2021 NBC | 45 | |
| S08E128 | Anna Kendrick, Wayne Federman, Masked Wolf | April 23, 2021 NBC | 45 | |
| S08E129 | Magic Johnson, Roger Daltrey, Moneybagg Yo | April 26, 2021 NBC | 45 | |
| S08E130 | Michael Che, Kate Upton, Nicki Nicole with special guest Lunay | April 27, 2021 NBC | 45 | |
| S08E131 | Luke Bryan, Brian Regan, Rupi Kaur | April 28, 2021 NBC | 45 | |
| S08E132 | Michael B. Jordan, Nate Bargatze, Coi Leray | April 29, 2021 NBC | 45 | |
| S08E133 | James Spader, Abbi Jacobson, Beach Bunny | April 30, 2021 NBC | 45 | |
| S08E134 | Vince Vaughn, Aidy Bryant, girl in red | May 3, 2021 NBC | 45 | |
| S08E135 | Andrew Garfield, Sara Bareilles, Renée Elise Goldsberry, Paula Pell, Busy Philipps, Thomas Rhett | May 4, 2021 NBC | 45 | |
| S08E136 | Channing Tatum, Josh Duhamel, Joyelle Nicole Johnson | May 5, 2021 NBC | 45 | |
| S08E137 | Jessica Alba, Marc Maron, Sech | May 6, 2021 NBC | 45 | |
| S08E138 | | May 7, 2021 NBC | 45 | |
| S08E139 | Leslie Jones, X Gonzalez, Weezer | May 10, 2021 NBC | 45 | |
| S08E140 | Joel McHale, Thalia | May 11, 2021 NBC | 45 | |
| S08E141 | Dave Chappelle, Nikki Glaser, J.Period ft. Black Thought and Tiffany Gouché with narration by Dave Chappelle | May 12, 2021 NBC | 45 | |
| S08E142 | | May 13, 2021 NBC | 45 | |
| S08E143 | Chance the Rapper, Fred Armisen, Alan Jackson | May 14, 2021 NBC | 45 | |
| S08E144 | P!nk, Eric Bana, Natti Natasha x Becky G | May 17, 2021 NBC | 45 | |
| S08E145 | Chris Rock, WILLOW | May 18, 2021 NBC | 45 | |
| S08E146 | Blake Shelton, Fran Lebowitz, Regard, Troye Sivan, Tate McRae | May 19, 2021 NBC | 45 | |
| S08E147 | Tina Fey, Wyatt Cenac, Dayglow | May 20, 2021 NBC | 45 | |
| S08E148 | Constance Wu, Bowen Yang, Lord Huron ft. Allison Ponthier | May 21, 2021 NBC | 45 | |
| S08E149 | Dave Grohl, Lil Nas X, Blake Shelton | May 24, 2021 NBC | 45 | |
| S08E150 | Kevin Hart, Chrissy Metz, St. Vincent | May 25, 2021 NBC | 45 | |
| S08E151 | Sofia Vergara, Jack Antonoff, Bleachers | May 26, 2021 NBC | 45 | |
| S08E152 | Michael Douglas, Billy Porter, Mustafa | May 27, 2021 NBC | 45 | |
| S08E153 | Julianne Moore, Dave Bautista, Twenty One Pilots | May 28, 2021 NBC | 45 | |
| S08E154 | | June 7, 2021 NBC | 45 | |
| S08E155 | | June 8, 2021 NBC | 45 | |
| S08E156 | Kristen Bell, Dane DeHaan, Migos | June 9, 2021 NBC | 45 | |
| S08E157 | Jason Momoa, Rose Byrne, Clairo | June 10, 2021 NBC | 45 | |
| S08E158 | Kathryn Hahn, Jon M. Chu, Polo G | June 11, 2021 NBC | 45 | |
| S08E159 | | June 14, 2021 NBC | 45 | |
| S08E160 | Salma Hayek, Dr. Anthony Fauci, Jessie Ware | June 15, 2021 NBC | 45 | |
| S08E161 | Seth Meyers, Annie Murphy, Coldplay | June 16, 2021 NBC | 45 | |
| S08E162 | Helen Mirren, Kenya Barris, Noel Gallagher's High Flying Birds | June 17, 2021 NBC | 45 | |
| S08E163 | Scarlett Johansson, Questlove, Graham Kay | June 21, 2021 NBC | 45 | |
| S08E164 | Vin Diesel, Riley Keough, Modest Mouse | June 22, 2021 NBC | 45 | |
| S08E165 | John Cena, Henry Winkler, Majid Jordan | June 23, 2021 NBC | 45 | |
| S08E166 | Jon Hamm, Ozuna, Rojo Perez | June 24, 2021 NBC | 45 | |
| S08E167 | Charlize Theron, Willie Nelson, beabadoobee | June 25, 2021 NBC | 45 | |
| S08E168 | Tom Hiddleston, Tig Notaro, Goldlink ft. Flo Milli | July 12, 2021 NBC | 45 | |
| S08E169 | BTS, Édgar Ramírez | July 13, 2021 NBC | 45 | |
| S08E170 | Don Cheadle, Cecily Strong, BTS | July 14, 2021 NBC | 45 | |
| S08E171 | Mark Wahlberg, Mark Hamill, John Mayer | July 15, 2021 NBC | 45 | |
| S08E172 | | July 19, 2021 NBC | 45 | |
| S08E173 | Jonas Brothers, Zoe Lister-Jones, Omar Apollo | July 20, 2021 NBC | 45 | |
| S08E174 | Emilia Clarke, Mark Ronson, Brandi Carlile | July 21, 2021 NBC | 45 | |
| S08E175 | Kate Beckinsale, Fred Armisen, Leon Bridges | July 22, 2021 NBC | 45 | |
| S08E176 | Matt Damon, Jason Sudeikis, Camila Cabello | July 23, 2021 NBC | 45 | |
| S08E177 | Billie Eilish, Abigail Breslin | August 9, 2021 NBC | 45 | |
| S08E178 | Barbra Streisand, Marlon Wayans, Snoh Aalegra | August 10, 2021 NBC | 45 | |
| S08E179 | Billy Crystal, Katie Ledecky, Jean Hanff Korelitz, Jackie Fabulous | August 11, 2021 NBC | 45 | |
| S08E180 | Kit Harington, Miranda Cosgrove, Duran Duran | August 12, 2021 NBC | 45 | |
| S08E181 | Melissa McCarthy, Jai Courtney, Little Simz | August 16, 2021 NBC | 45 | |
| S08E182 | Michael Shannon, Paris Hilton, Courtney Barnett | August 17, 2021 NBC | 45 | |
| S08E183 | Michael Keaton, Heidi Klum, Vince Staples ft. Fousheé | August 18, 2021 NBC | 45 | |
| S08E184 | | August 19, 2021 NBC | 45 | |
| S08E185 | Kelly Clarkson, Yahya Abdul-Mateen II, Bakar | August 23, 2021 NBC | 45 | |
| S08E186 | Andy Samberg, Madelyn Cline, Andrea Bocelli | August 24, 2021 NBC | 45 | |
| S08E187 | Molly Shannon, Eugenio Derbez, Chvrches | August 25, 2021 NBC | 45 | |
| S08E188 | Camila Cabello, Ryan Tedder, OneRepublic | August 26, 2021 NBC | 45 | |
| S08E189 | Trevor Noah, Beanie Feldstein, Gorillaz ft. AJ Tracey | September 7, 2021 NBC | 45 | |
| S08E190 | Pete Davidson, Meredith Hagner, Baby Keem | September 8, 2021 NBC | 45 | |
| S08E191 | John Cena, J Balvin | September 9, 2021 NBC | 45 | |
| S08E192 | Reese Witherspoon, Simu Liu, Lisa | September 10, 2021 NBC | 45 | |
| S08E193 | Andrew Garfield, Patton Oswalt, A Performance from Little Shop of Horrors | September 13, 2021 NBC | 45 | |
| S08E194 | Kendall Jenner, Antoni Porowski, A Performance from Tina - The Tina Turner Musical | September 14, 2021 NBC | 45 | |
| S08E195 | Ben Platt, JoJo Siwa | September 15, 2021 NBC | 45 | |
| S08E196 | Amy Adams, Billy Crudup, A Performance From SIX | September 16, 2021 NBC | 45 | |
| S08E197 | Jennifer Aniston, Amandla Stenberg, A Performance from Wicked season finale | September 17, 2021 NBC | 45 | |
